INCREASED OXPHOS ACTIVITY PRECEDES RISE IN GLYCOLYTIC RATE IN H-RASV12/E1A TRANSFORMED FIBROBLASTS THAT DEVELOP A WARBURG PHENOTYPE

Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype

Abstract Background The Warburg phenotype in cancer cells click here has been long recognized, but there is still limited insight in the consecutive metabolic alterations that characterize its establishment.We obtained better understanding of the coupling between metabolism and malignant transformation by studying mouse embryonic fibroblast-derived

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Computational methods meet in vitro techniques: A case study on fusaric acid and its possible detoxification through cytochrome P450 enzymes

Mycotoxins are known environmental pollutants that may contaminate food and feed chains.Some mycotoxins are regulated in many countries to limit the trading of contaminated and harmful commodities.However, the so-called emerging mycotoxins are poorly understood and need to be investigated further.Fusaric acid is an emerging mycotoxin, noxious to pl

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